Anti Smooth Muscle Antibody (Qualitative)

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    blood sample




    Age group

    Above 10 years

    An anti-smooth muscle antibody test is a diagnostic check that identifies autoantibodies known to attack smooth muscle cells in the body, most often in the liver. Autoantibodies are antibodies produced by the body that assault the body cells.

    Usually, the immune system will use antibodies created to defend the body. It combats foreign bodies such as parasites or viruses. However, anti-smooth muscle antibodies mistake the body's cells and tissues for external entities and instruct the immune system to attack them.

    Anti-smooth muscle antibodies, or ASMAs, target smooth muscle tissues within the body. If a person has chronic liver diseases, their healthcare practitioner will most likely order an anti-smooth muscle antibody test. The test can aid in the detection of active autoimmune hepatitis.

    The most common cause of hepatitis is viruses. However, autoimmune hepatitis arises when the immune system starts targeting the liver cells. It is a chronic disorder that can lead to cirrhosis or scarring of the liver and, eventually, liver failure.

    Therefore, recognising the signs and symptoms of autoimmune hepatitis or any other liver disease is vital. Some of the symptoms are as follows:

    • Appetite suppression
    • Dark urine
    • Fatigue
    • Gastrointestinal discomfort
    • Hepatomegaly or enlarged liver
    • Itchiness
    • Jaundice or the yellowing of skin and eyes
    • Joint pain
    • Nausea
    • Pale-coloured stools
    • Skin rash
    • Swelling or abdominal distension
    • Tenderness around the liver
    • Vomiting

    When the quantity of anti-smooth muscle antibodies within the blood sample matches a titer larger than 1:40, the medical community considers the findings abnormal.

    These findings may indicate that a person has any of the following:

    • Autoimmune liver problems
    • Chronic hepatitis c infection
    • Infectious mononucleosis
    • Breast or ovarian cancers
    • A malignant melanoma

    When anti-smooth muscle antibody levels elevate, a doctor will order more testing to establish the cause. They may also request an F-actin antibody test to look for antibodies that might indicate hepatitis. If the findings are ambiguous, a doctor may have to repeat the test.

    After discovering the cause of the elevated anti-smooth muscle antibody levels, the doctor will confirm and explain the diagnosis. Further, he will develop a treatment plan fully suited to the patient.

    If the test comes out positive, it is critical to find a doctor specialising in liver diseases and autoimmune illnesses. If a patient does not exhibit symptoms, a doctor may opt not to treat them. They will, however, recommend frequent blood testing, including the anti-smooth muscle antibody test, as well as other tests to observe the liver's condition.

    The anti-smooth muscle antibody test is available on the Apollo 24|7’s website and can be booked with a simple click.

    Nevertheless, if the symptoms of autoimmune hepatitis become more frequent, doctors will use steroids as the first-line therapy. The long-term consequences of anti-smooth muscle antibodies, particularly autoimmune hepatitis, are tough to predict, and the sickness might be severe or chronic. 

    faqFrequently Asked Questions (FAQs)

    Frequently asked questions

    Anti-smooth muscle antibodies most commonly attack smooth muscle tissues in the liver. It results in illnesses such as autoimmune hepatitis and primary biliary cirrhosis. Immunosuppressive medicines can help treat autoimmune hepatitis if it is detected early. However, it may result in liver failure if not treated on time.
    One should get tested for autoimmune hepatitis if they experience symptoms such as nausea, yellowing of the skin and eyes, changes in appetite, stomach aches, and joint pain.
    Autoimmune hepatitis is classified into two types: Type 1 is the most prevalent type of the illness, affecting people who already have another autoimmune disease. On the other hand,  Type 2 is a less prevalent variant of the condition that primarily affects girls aged 2 to 14.
    Untreated autoimmune hepatitis can result in irreversible scarring of the liver tissue known as cirrhosis. It can also lead to problems such as vein enlargement, liver failure, or cancer.
    While there is no definitive proof that autoimmune hepatitis is inherited genetically, there is evidence that autoimmune hepatitis may, at times, run in families.
    This test can assist a doctor in determining whether a patient has a liver condition such as primary biliary cirrhosis, or primary sclerosing cholangitis. However, it can also indicate chronic hepatitis C infection, infectious mononucleosis, breast or ovarian cancer, or melanoma.

    Why should Apollo be your preferred healthcare partner?

    • 40 Years of legacy and credibility in the healthcare industry.
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    • Affordable diagnostic solutions with timely and accurate test results.
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    • An inventory of over 100+ laboratories, spread across the country, operating out of 120+ cities with 1200+ collection centers, serving over 1800+ pin codes.

    The information mentioned above is meant for educational purposes only and should not be taken as a substitute to your Physician’s advice. It is highly recommended that the customer consults with a qualified healthcare professional to interpret test results