What happens in brain during depression?

Answered by 1 Apollo Doctors

Dr Mubarak Parveez B

General Practitioner

MBBS
2+ Yrs

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Hippocampus in the brain releases cortisol. The influx of cortisol triggered by depression causes the amygdala to enlarge. This is a part of the brain associated with emotional responses. When it becomes larger and more active, it causes sleep disturbances, changes in activity levels, and changes in other hormones.

Answered 04/07/2025

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