C1 Esterase Inhibitor

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    blood sample




    Age group

    Above 10 years

    A body's inherent job is to protect itself from viruses and bacteria. It can do so either with the help of antibodies or through a solid immune system. It's this system that reacts to potential threats proactively before the antibodies are formed.

    This system is made up of a complement system which comprises nine major proteins – C1 to C9. These proteins recognize any foreign cell that can potentially cause any ailment. With the help of blood tests, it is essential to monitor the deficiencies and keep the protein levels in check.

    C1 esterase inhibitor (C1-INH) test is a blood test that measures the level and activity of a protein called C1 esterase inhibitor in the blood. C1-INH is an important protein that plays a crucial role in regulating the complement system and the kinin-kallikrein system, both of which are part of the immune system.

    So, if you are suffering from any of the following symptoms, a C1 esterase inhibitor test can help determine the cause behind it:

    • Swelling in hands, feet, airway, face and gastrointestinal wall
    • Vomiting and nausea
    • Abdominal pain
    • Unexplained inflammation, also known as Edema

    If the doctor has prescribed the test to monitor the protein levels, book the C1-INH test at Apollo 24|7.

    Getting this C1-INH test will help:

    • Confirm if you are suffering from any inexplicable Inflammation, Edema or Congenital Inflammatory Disorder
    • Assure if the treatment method for Inflammation, Edema or Congenital Inflammatory Disorder is suitable for you
    • Diagnose the disease of hereditary angioedema
    • Diagnose the deficiency of complement protein levels
    • Assess your body’s response to the treatment of autoimmune diseases like systemic lupus erythematosus.

    There are no specific steps required to ready yourself for the C1 esterase inhibitor test, except for fasting for 10 to 12 hours. It’s a simple blood test that hardly takes a few minutes. It's very minimally invasive yet involves the potential risks of:

    • Excessive bleeding
    • Fainting
    • Infection at the injection site
    • Difficulty obtaining blood, thus causing multiple needles pokes
    • Blood accumulation under the skin, also known as a hematoma

    Normal results of C1-INH test generally oscillate between the range of 16 milligrams to 33 milligrams per deciliter.

    Abnormal results of C1-INH tests usually indicate the presence of angioedema. Angioedema can potentially cause sudden swelling in the face, tongue or upper throat. It can also make breathing a difficult task. Additionally, it may also result in abdominal pain and swelling in the intestines.

    Angioedema can be observed both in children and older adults. Often, the older adults suffering from angioedema may also be found dealing with other medical conditions like autoimmune disease or cancer.

    faqFrequently Asked Questions (FAQs)

    Frequently asked questions

    C1-INH or C1 esterase inhibitor is a protein spotted in your blood fluid. It specifically controls a protein called C1, which forms a part of the complement system. This complement system comprises a group of 60 proteins (C1 to C9 are nine major proteins) found in blood plasma.
    This deficiency is a rare condition linked with low-grade lymphoproliferative or autoimmune disorders. Usually, it is observed in elderly adults who have a recurrent condition of angioedema or lower levels of C4 with apt levels of C3. A C1 esterase inhibitor test will help you detect these deficiencies accurately.
    If C1-INH is low, it may cause several kinds of angioedema. So, you may struggle with swelling on your face, tongue or upper throat. It may also lead to difficulty in breathing. Further signs of low C1-INH include abdominal pain and intestinal swelling.
    A C1-INH test can help determine if you are suffering from hereditary angioedema. The early signs of this disease include: Tingling skin Fatigue Sudden mood swings Non-itchy and painless rashes Skin tightness Irritability Anxiety
    If your blood test indicates a high or low C1-INH level, then it can be a sign of: Malnutrition Acquired or hereditary angioedema  Recurring bacterial infection Systemic Lupus Erythematosus (SLE) Blood infection or septicaemia Kidney diseases like membranous nephritis, lupus nephritis, glomerulonephritis
    A C1-INH test is a blood test. It's very minimally invasive yet involves the potential risks of: Excessive bleeding Fainting Infection at the injection site Difficulty obtaining blood, thus causing multiple needles pokes Blood accumulation under the skin, also known as a hematoma
    If the C1-INH levels are low, it may result in two types of angioedema. One is the hereditary angioedema which occurs in kids and young adults under the age of 20. Another is acquired angioedema which is observed in adults older than 40. In cases of acquired angioedema, adults are likely to suffer from other autoimmune diseases or cancer.

    Why should Apollo be your preferred healthcare partner?

    • 39 Years of legacy and credibility in the healthcare industry.
    • NABL certified multi-channel digital healthcare platform.
    • Affordable diagnostic solutions with timely and accurate test results.
    • Up to 60% discount on Doorstep Diagnostic Tests, Home Sample Collection.
    • An inventory of over 100+ laboratories, spread across the country, operating out of 50+ cities with 700+ collection centres, serving over 1800+ pin codes.

    The information mentioned above is meant for educational purposes only and should not be taken as a substitute to your Physician’s advice. It is highly recommended that the customer consults with a qualified healthcare professional to interpret test results

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