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    blood sample




    Age group

    Above 10 years

    Cholinesterase is an enzyme that supports the proper functioning of the nervous system. There are two types of cholinesterase:

    • Acetylcholinesterase: These are found in RBCs of lungs, spleen, nerve endings, and the brain’s grey matter.
    • Pseudocholinesterase: You can find them in serum, liver, muscle, pancreas, the white matter of the brain, and the heart.

    The enzyme plays a vital role in transmitting the nerve impulse by breaking down the neurotransmitter acetylcholine. A reduction in the activity of the cholinesterase leads to an excess of acetylcholine in the nerve ending, leading to overstimulation of nerves within the body.

    A serum cholinesterase test identifies the efficacy of the nervous system function to avoid overstimulation of post-synaptic nerves, exocrine glands, and muscles. Your doctor may suggest the cholinesterase test to:

    • Detect liver disorders.
    • Rule out the possibility of apnea before administering anaesthesia.
    • Find an infection in the body. 
    • Determine the possibility of liver damage, heart attack, and obstructive jaundice. 
    • Diagnose metastasis of a cancerous growth.
    • Check pesticide or insecticide poisoning.
    • Diagnose inflammation due to a severe disease. 
    • Assess chronic malnutrition in an individual.
    • Examine a family history of postoperative paralysis.
    • Manage the occupational hazard of working around chemicals like organophosphates.

    Apollo 24|7 has an all-inclusive panel for blood cholinesterase test to measure the following parameters: 
    Organophosphate pesticide exposure: Most insecticides and pesticides contain organophosphates that inhibit the activity of cholinesterase and pseudocholinesterase. These chemicals can enter the system by inhalation, ingestion, or epidermal exposure. Hence, finding out the levels through a blood cholinesterase test can estimate the level of poisoning in the body. This further aids in reducing occupational exposure to the chemicals.

    Pseudocholinesterase deficiency: Some individuals have a genetic disorder that causes the lack of pseudocholinesterase. As a result, the individual experiences a long-lasting effect of powerful drugs. In such a case, muscle relaxants and anaesthesia lead to apnea and muscle paralysis. Hence, the more extended bioavailability of drugs could cause severe complications in the body.

    A blood cholinesterase test is essential because inactivity of the enzyme causes impairment of neuromuscular junction. The muscles remain at the contracted stage until the enzyme breaks down the molecule into choline and acetic acid. This tension in the muscle could lead to severe conditions, which might become permanent.

    Below are some of the symptoms that can be taken as a sign to go for a serum cholinesterase test: 

    • Nausea, dizziness, and headache
    • Watery eyes with irritation
    • Excessive salivation or sweating
    • Diarrhoea or vomiting
    • Constriction in pupils leading to vision problems 
    • Impaired muscle coordination 
    • Constantly in need of ventilation due to breathing difficulties

    In addition, many severe cases may lead to seizures, coma, and death. The starting signs of going for a blood cholinesterase test could be the twitching of muscles. 

    faqFrequently Asked Questions (FAQs)

    Frequently asked questions

    The blood cholinesterase test results are accurate after doing the test in triplicates. However, a 35% drop in the enzyme levels from the baseline indicates severe poisoning.
    After observing the symptoms, one should go to a general practitioner or a general physician. In most cases, you might receive a reference for a toxicologist, emergency physician, or intensivist. These healthcare professionals might suggest you take a serum cholinesterase test. You can also consult with an occupational health physician for assistance.
    The normal range for the enzyme varies between 8 and 18 U/mL. The variation also depends on the techniques used for testing and an individual’s body conditions. However, a baseline gives a standard value to compare the results with.
    Factors like pregnancy and consumption of birth control pills could show slightly lower cholinesterase values. However, these values are easily distinguishable because the enzyme level does not fall beyond 35%.
    A serum cholinesterase test can be taken several days before the surgery to rule out the possibility of postoperative paralysis. This not only helps in managing the condition but also allows the surgeon to adopt a different approach.

    Why should Apollo be your preferred healthcare partner?

    • 40 Years of legacy and credibility in the healthcare industry.
    • NABL certified multi-channel digital healthcare platform.
    • Affordable diagnostic solutions with timely and accurate test results.
    • Up to 60% discount on Doorstep Diagnostic Tests, Home Sample Collection.
    • An inventory of over 100+ laboratories, spread across the country, operating out of 120+ cities with 1200+ collection centers, serving over 1800+ pin codes.

    The information mentioned above is meant for educational purposes only and should not be taken as a substitute to your Physician’s advice. It is highly recommended that the customer consults with a qualified healthcare professional to interpret test results