Coombs Test (Indirect)

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Effective price: ₹707

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    blood sample




    Age group

    Above 10 years

    The Coombs Test (Indirect) is also known as the RBC antibody screen test, Indirect antiglobulin test, Indirect anti-human globulin test, or antibody screen test. This test helps to detect antibodies that are directed against red blood cell antigens. The Coombs Test (Indirect) is done: • At the time of blood transfusion • To check for Rh incompatibility in a pregnant woman • To detect hemolytic disease in newborn

    faqFrequently Asked Questions (FAQs)

    Frequently asked questions

    To take the blood sample, a tourniquet (elastic) band is placed tightly on the upper arm. The patient is asked to make a fist. This helps in the buildup of blood filling the veins and it becomes easy to collect the blood. The skin is cleaned before inserting the needle in the vein in order to prevent bacteria from entering. The needle is then inserted into the vein in the arm and the blood sample is collected in the vacutainer.
    The Direct Coombs test is done to detect the presence of antibodies that are directed against one’s own RBCs that occurs in cases of autoimmune diseases. The Indirect Coombs test helps to detect the presence of RBC antibodies that are external. The antibodies detected by the Direct Coombs test are present on the surface of RBCs while the antibodies detected by the Indirect Coombs test are found in the serum.
    The Indirect Coombs test can be used to detect hemolytic anemia that can occur due to autoimmune conditions. The autoimmune hemolytic anemia can be seen in autoimmune diseases like Systemic Lupus Erythematosus, Mycoplasma pneumonia infections, or certain cancers such as lymphoma and lymphocytic leukemia.
    The Hemolytic Disease of the fetus and newborn (HDFN) is a condition in which the blood type of the mother and the fetus are incompatible with each other. In such cases, antibodies are produced in the mother that can cross the placenta and cause reactions to the RBC of the fetus resulting in HDFN.
    The other test that is advised in the case of positive Indirect Coombs test include Antibody Identification test as it helps to identify the type of antibodies present in the blood.

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    The information mentioned above is meant for educational purposes only and should not be taken as a substitute to your Physician’s advice. It is highly recommended that the customer consults with a qualified healthcare professional to interpret test results