I'm having some trouble with gastric issues and I'm trying to figure out if itopride is a safe option. Also, are the modes of action for itopride and levosulpride the same or are there some differences I should be aware of?

Answered by 1 Apollo Doctors

Dr Ibrahim Salah

General Practitioner

MBBS
2+ Yrs

Consult Now

itopride is primarily used for gastrointestinal motility issues and has fewer neurological side effects. Levosulpiride is also used for gastrointestinal issues but can affect mood and has stronger sedative effects at higher doses due to its impact on dopamine and serotonin.Both drugs block dopamine D2 receptors, but Itopride also has cholinergic effects, stimulating acetylcholine release to aid digestion. This may make Itopride somewhat more specific for treating GI conditions. Levosulpiride, in addition to its prokinetic effects, has a neuropsychiatric effect, which makes it more effective for treating conditions like anxiety or depression at higher doses

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Answered 04/07/2025

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