My wife has been dealing with TB since February 2017 and she's been on 3 FDC treatment. A few months after starting, we went through a biopsy and she continued with medication. Now she's having some trouble with her legs. Have you seen something like this before or is it common for TB medication to cause leg issues? What should we do next?

Dr Shubham Chauhan

General Practitioner

• MBBS
• 4+ Yrs

Consult Now

Its important to inform her TB specialist about the leg symptoms. They can determine if the issue is a side effect of the medication or if it's related to something else. Evaluate for Peripheral Neuropathy: If the leg pain or weakness is due to nerve damage (which is common with Isoniazid), they might consider giving Vitamin B6 supplementation (to help with neuropathy), or they might change her medication regimen. Nerve or Bone Imaging: If there is suspicion that the TB has affected her bones or joints, further imaging (like X-rays, MRI, or bone scans) may be needed. Blood Tests: To check for any liver toxicity or vitamin deficiencies (such as Vitamin B12, Vitamin D, or calcium).

Answered 04/07/2025